Larry D. Simms Jr., 24, of Waterville and Eddie Cabassa were arrested after police caught them trying to flush more than 100 grams of lump, crack cocaine down a toilet.
Police said the rock was two-thirds the size of a softball.
The cocaine reportedly clogged the toilet, requiring the Winslow Public Works Department to remove the toilet from the floor and haul it away for police as evidence.
Winslow Police Chief Richard Grindall said it was the largest crack cocaine bust in memory. He said the estimated street value of the crack is between $7,500 and $10,000
Both men are charged with aggravated trafficking and with falsifying evidence for allegedly trying to flush away the drugs.
They each face up to 30 years in prison.
Simms is charged additionally with possession of another drug and with violating the conditions of his release.
An indictment is not a determination of guilt, but is rather a conclusion that there is enough evidence against a defendant to proceed with a trial in Superior Court.
Other indictments handed down this week include drug charges against Dan M. Danforth, 37, of Canaan, charged by the grand jury with aggravated trafficking and possession of the narcotic Oxycodone. The crimes are alleged to have happened in Sidney in December.
The trafficking charge is a Class A felony, punishable by up to 30 years in prison.
Also indicted by the grand jury was Frank Gonzales, 52, of Waterville, charged on eight separate criminal charges.
Gonzales is charged with felony burglary of a home in Waterville Jan. 12, assault, aggravated criminal trespass, criminal mischief, violating a protection order and other charges the same day against the same female victim, according to the grand jury.
He also is charged with violating a protection order on Jan. 11 for having contact with the same woman at her residence.
Other indictments include:
Joseph A. Oliveira Jr., 18, of Charleston, on charges of furnishing cocaine last Dec. 5 in Waterville. He is charged additionally with operating after suspension, failure to give his correct name and with attaching improper motor vehicle registration plates.
Jacob Olivares, 27, of Waterville, charged with trafficking in Oxycodone, Jan. 11, in Waterville.
n Peter J. Dubord, 47, of Augusta, indicted on a charge of criminal operating under the influence. Aug. 30, 2007, in Waterville. Dubord has two prior OUI convictions within the past 10 years.
He also is charged with operating beyond license restriction the same day.
Shane Leslie Wood, 40, of Vassalboro, charged by the grand jury with marijuana cultivation and trafficking in more than a pound of marijuana last December. He is charged additionally with violating the conditions of his release in January.